Report on the buccal micronucleus assay workshop organized by the International Human Micronucleus (HUMN) project--Antalya, Turkey 2007
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منابع مشابه
Report on the buccal micronucleus assay workshop organized by the International Human Micronucleus (HUMN) project--Antalya, Turkey 2007.
This report describes the aims, discussion and outcomes of the first Human Micronucleus collaborative project workshop on the buccal micronucleus assay. It was agreed at the workshop that three activities should be initiated as soon as possible namely (i) a method for collection of databases, (ii) writing of a protocol based on the most commonly used and best validated procedures and (iii) an i...
متن کاملHarmonisation of the micronucleus assay in human buccal cells--a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007.
Michael Fenech*, Claudia Bolognesi, Micheline Kirsch-Volders, Stefano Bonassi, Errol Zeiger, Siegfried Knasmüller and Nina Holland CSIRO Human Nutrition, Adelaide, Australia, Unit of Environmental Carcinogenesis, National Cancer Research Institute, Genoa, Italy, Laboratory for Cell Genetics, Vrije Universiteit Brussel, Brussel, Belgium, Unit of Molecular Epidemiology, National Cancer Research I...
متن کاملState of the art survey of the buccal micronucleus assay--a first stage in the HUMN(XL) project initiative.
The study of DNA damage in exfoliated buccal cells is a minimally invasive method for monitoring populations for exposure to genotoxic agents. The presence of micronuclei (MN) and other nuclear anomalies within these cells has been shown to be associated with genetic defects in genome maintenance, accelerated ageing, genotoxic damage and some degenerative diseases. To identify important informa...
متن کاملThe HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells--past, present and future.
The International Human Micronucleus (HUMN) Project (www.humn.org) was founded in 1997 to coordinate worldwide research efforts aimed at using micronucleus (MN) assays to study DNA damage in human populations. The central aims were to (i) collect databases on baseline MN frequencies and associated methodological, demographic, genetic and exposure variables, (ii) determine those variables that a...
متن کاملThe HUman MicroNucleus project on eXfoLiated buccal cells (HUMN(XL)): the role of life-style, host factors, occupational exposures, health status, and assay protocol.
The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used techniques to measure genetic damage in human population studies. Reducing protocol variability, assessing the role of confounders, and estimating a range of reference values are research priorities that will be addressed by the HUMN(XL) collaborative study. The HUMN(XL) project evaluates the impact of host factor...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2008
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/gen065